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What is the most disastrous human emotion? William Shakespeare’s Othello makes it clear that the answer to this question is jealousy. After all, it is jealousy that drives Iago to concoct the plan, which ruins the lives of several innocent people including Othello, Desdemona, Emilia, and Roderigo. T Jealousy in Othello In Shakespeare's Othello, Iago plots Othello's destruction when he is passed over for a promotion. Iago tells Othello that Desdemona has been unfaithful to him and provides circumstantial evidence for this.