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Prions
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Proteinaceous infectious particles, known as prions, were discovered to be the cause of similar types of degenerative disorders of the central nervous system in humans and other mammals (1). ... How prions damage individual cells is still uncertain. There is even some uncertainty in the scientific community as to whether prions are the cause of disease (5,6).
Prions are a unique pathogen in that they consist entirely of protein. ... Stanley Prusiner showed that breaking down nucleic acid failed to stop the growth of prions. ... This similar protein is the “major, if not the only component of prions” (3).
Prions can exist in two forms. ...
There is still uncertainty how prions damage cells. ... Scrapie type prions are resistant to proteases and are thought to accumulate within the lysosomes of neurons (12). These cells could conceivably swell with added prions and burst, creating a hole and releasing their prions. ... A specific antibody is tagged with a fluorescent dye to detect the infectious prions. ...
Although skeptics of prions remain, the scientific community has generally accepted the prion hypothesis (4).
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Paper Information
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Title: Prions
Words: 824
Rating: None
Pages: 3.3
submitted by: tfromm1
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