Papers > Science > Pharmacology of Thromboxane A2
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Pharmacology of Thromboxane A2
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Thromboxane A2 (TxA2) is one of several eicosanoid products (metabolite product from Arachidonic Acid through COX pathway) generated by most vertebrate cell types and has a wide variety of biological activities, which may participate in pain and inflammatory responses. ... Besides, DAG which remains bound on plasma membrane will activate PKC (protein kinase C), that exerts further regulation such as elevate vascular tone, activation of phospholipase A2 to cleave phospholipids to arachidonic acid and lead to eicosanoid production, regulation of gene expression, and so forth. ...
Because aspirin also prevents the synthesis of PGI2, specific thromboxane receptor antagonists that specifically impair the effects of TxA2, might be clinically advantageous. Pinane thromboxane A2 (PTA2), a TxA2 analog has been shown to antagonize the vasoconstriction and platelet aggregation. Besides acting as a TxA2 receptor antagonist, it also specifically inhibits thromboxane synthetase. Because TxA2 generation would be detrimental in acute myocardial ischemia by both decreasing coronary blood flow and increasing platelet aggregation, inhibition of thromboxane production and action may be beneficial in myocardial ischemia. ... Ozagrel hydrochloride was the first thromboxane modulator released onto the market for the treatment of adult bronchial asthma. It is a selective thromboxane synthase inhibitor, preventing the induction of airway hyperresponsiveness provoked by TxA2.
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Paper Information
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Title: Pharmacology of Thromboxane A2
Words: 1197
Rating: None
Pages: 4.8
submitted by: Stephy
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