Papers > Technology > NEURODEGENERATIVE DISEASEA puff a day keeps the plaques away?
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NEURODEGENERATIVE DISEASEA puff a day keeps the plaques away?
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Can smoking have a neuroprotective effect? The recent observation that exposure to nicotine delays the onset of Alzheimer's disease has researchers racing to identify the mechanism of this surprising phenomenon. Most studies have focused on nicotine itself — few have considered the contribution that metabolites of nicotine, the principal alkaloid component of tobacco, might make to neuroprotection. Now, a study published in the Proceedings of the National Academy of Sciences shows that nornicotine — a product of the N-demethylation of nicotine — inhibits the formation of the amyloid -peptide (A ) fibrils whose aggregation into neuritic plaques is a hallmark of this devastating disease.
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Paper Information
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Title: NEURODEGENERATIVE DISEASEA puff a day keeps the plaques away?
Words: 315
Rating: None
Pages: 1.3
submitted by: rebeccagazder
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